Multifunctional Methotrexate-Laden Nanotherapy Modulates the Joint-Brain Axis and Attenuates Associated Neuroinflammation in an Experimental Model of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovial inflammation, cartilage erosion, and systemic manifestations, including cognitive and neuropsychiatric complications. Increasing evidence highlights the bidirectional interplay of the joint-brain axis between peripheral inflammati...