Jatuporn Ngoenkam

The Y105 phosphosite between the SH3.1 and SH3.2 domains of Nck1 regulates its binding to CD3ϵ

Summary In αβ T cells, ligand binding to T cell receptor (TCR) triggers conformational changes at CD3ε subunits to expose the proline-rich sequence (PRS), which binds to the non-catalytic region of tyrosine kinase (Nck) via its Src homology 3 (SH3).1 domain. Recruitment of Nck to CD3ε initiates phosphorylation of vario...

Biosynthetic Gene Cluster Mining and In Vitro Evaluation of the Antimicrobial and Cytotoxic Potential of Xenorhabdus thuongxuanensis

Xenorhabdus species are prolific producers of diverse bioactive natural products. However, the genomic characteristics, biosynthetic potential, and biological activities of Xenorhabdus thuongxuanensis remain poorly characterized. This study aimed to characterize the genomic features and biosynthetic potential of X. thu...

Heat shock protein family D member 1 (HSPD1) modulates ribosome-related pathways and protein synthesis in lung adenocarcinoma