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Author

Javier Egea

1 paper indexed here

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Sep 2026

MCC950-Derived NLRP3 Inflammasome Inhibitor Modulates Glial Inflammatory Signatures and Neuroinflammation after Traumatic Brain Injury

The NLRP3 inflammasome is a central mediator of sterile inflammation and a key therapeutic target to modulate secondary neuroinflammation following traumatic brain injury (TBI). Although the widely used NLRP3 inhibitor MCC950 effectively suppresses inflammasome activation in preclinical models, its clinical developme...

Céline Decouty-Pérez, María Álvarez-Rubal, Icíar Polo-Fernández et al. · 0 citations

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