Open access
Jul 2026
Reoxygenating the Tumor Microenvironment with Biomimetic Hemoglobin Nanoparticles Enhances Chemo, CAR-T, and Gene Therapies 2260007
Hb-BNPs reoxygenate hypoxic tumors, suppress HIF-1α signaling, suppress HIF-1α signaling, and restore cytotoxic immune function without inducing inflammation, offering a scalable, immune-tolerant platform to overcome hypoxia-driven resistance in solid tumors.
H. Gandhi, Jaydeep Bhattacharya
· Journal of Immunology · 0 citations