Open access
Sep 2026
The 4EHP/GIGYF2 translation repressor complex is co-opted by the vaccinia virus K3L protein as a potential mechanism of immunoevasion.
It is demonstrated that the vaccinia virus-encoded K3L protein interacts with 4EHP via its obligatory binding partner GIGYF2 to increase the stability of the 4EHP/GIGYF2 complex and bolsters 4EHP/GIGYF2-mediated mRNA translation repression.
R. Ladak, A. Pelin, Hao-Tian Zhuang et al.
· Proceedings of the National... · 0 citations