Therapeutic Efficacy of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Critical Limb Ischemia: A Preclinical Systematic Review and Meta-Analysis with Source-Specific Subgroup Analysis.
BACKGROUND Critical limb ischemia (CLI), the most advanced stage of peripheral arterial disease, is associated with substantial risks of limb loss and mortality. As many patients are ineligible for revascularization, novel regenerative therapies are needed. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs)...