Sep 2026
Chimeric IL-15 as a next-generation immunotherapeutic: preclinical assessment of efficacy and safety.
Interleukin-15 (IL-15) is a potent immunostimulatory cytokine but is limited by rapid clearance and systemic toxicity. To overcome these limitations, our laboratory generated a chimeric IL-15 by fusing human IL-15 to the murine IgG2a Fc domain and evaluated its activity, efficacy, pharmacokinetics, and safety. The puri...
Himali Patel, M. Ahuja, Keyur Shah et al.
· International Immunopharmaco... · 0 citations