Mammalian metabolic engineering advances basic biology, bioproduction and cell therapy. However, as pathway complexity increases, so does the size of the combinatorial design space and required DNA constructs, rendering unbiased screens intractable. Here, we developed shotgun genetic engineering (SGE), which exploits t...
Julie Trolle, Sofia Sessa, A. Wudzinska et al.· Nature Biotechnology· 1 citation
The rapid pace of innovation in synthetic biology and genome engineering elicits a need to reevaluate systems of oversight to ensure that biosafety and biosecurity safeguards are keeping up. Accordingly, the regulation of nucleic acid synthesis, an enabling technology for synthetic biology and genome engineering, is a...
C. Chapman, Julie Trolle, Dominika Wawrzyniak et al.· Frontiers in Bioengineering...· 0 citations
This study provides a robust framework for modeling human-specific regulatory disorders and demonstrates the critical impact of non-coding variation on disease pathogenesis.
Ryan D. Fine, B. Low, Jarod A. Rollins et al.· bioRxiv· 0 citations
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