Author

Jeffrey J. Bajramovic

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Review Open access Sep 2026

Finding a place for new approach methodologies (NAMs) in biomedical research.

New approach methodologies (NAMs) can greatly contribute to the replacement and reduction of animal experiments in biomedical science. However, while NAMs have seen considerable investment and adoption in toxicology, this growth has not found a parallel in basic and translational biomedical research. Here we examine th...

A. Schaffert, Arti Ahluwalia, Jeffrey J. Bajramovic et al. · Lab animal · 0 citations

Sep 2026

Beyond NAMs versus animal models: Context of use as the governing framework for integrated nonclinical strategies in drug development.

New approach methodologies (NAMs) originated in chemical hazard assessment, where two forces operate together: the scale of characterizing many substances, and a long-standing ethical and legal commitment to replacing animal testing. Drug development is weighted differently. It is a translational and decision problem a...

Stefano Gaburro, B. Berridge, Nicholas W. Kelley et al. · Regulatory toxicology and ph... · 0 citations