Author

Jeffrey W. Bode

2 papers indexed here

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Open access Sep 2026

A designed ubiquitin-binding protein selectively enriches and visualizes unanchored ubiquitin

While protein ubiquitination has been extensively studied, the roles of unanchored ubiquitin and its chains remain less understood, largely due to a lack of specific, high-affinity tools for their enrichment and visualization. To address this, we used high-throughput affinity maturation and computational protein design...

Shi-Hua Shi, A. Bendel, G. Kempf et al. · Science Advances · 0 citations

Open access Sep 2026

Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles

The design, iterative synthesis, and comprehensive property profiling of a novel chemical library of shape-defined, morpholine-containing pentacycles revealed promising drug-like properties, including broad aqueous solubility, metabolic stability, low cytochrome P450 inhibition, and tunable membrane permeability.

E. Boschi, Dmitry Mazunin, Alex Mueller et al. · Chemical Science · 0 citations