In silico and in vitro NAMs including quantitative systems pharmacology (QSP) modeling for opioid overdose scenarios, (quantitative) structure–activity relationship ((Q)SAR) modeling for toxicity prediction and drug–drug interaction assessment, and multi‐omics approaches for pharmacodynamic biomarker discovery are desc...
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi et al.· Clinical pharmacology and th...· 0 citations
Model‐informed drug development (MIDD) approaches are being increasingly used in neuroscience drug development programs and regulatory decision‐making. In this work, the authors summarize a select set of cases in neurology, psychiatry, addiction, anesthesia, and analgesia, where MIDD approaches were utilized to address...
Michael Bewernitz, A. Nookala, Gopichand Gottipati et al.· Journal of clinical pharmaco...· 0 citations
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