Aug 2026
Design of fluorinated triazinoindoles as highly potent and markedly selective ALR2 inhibitors: synthesis, in silico and in vitro evaluation of promising lead compounds.
This study demonstrates that strategic fluorination is an effective approach for improving the potency and selectivity of ALR2 inhibition and identifies (8-F)OTI as a promising lead compound for further optimization and biological evaluation.
L. Kováčiková, Terezia Teplanova, M. Májeková et al.
· Bioorganic chemistry (Print) · 0 citations