Author

Jenna S. Caswell

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Open access Oct 2026

Loss of LKB1 protects against acetaminophen hepatotoxicity in mice through sex-specific mechanisms.

LKB1 regulates CYP2E1 and the PPP, that mitochondrial CYP2E1 is critical in APAP toxicity, and PPP activation is a potential therapeutic approach in liver injury in men and women is concluded.

Debasree Bhadra, Jenna S. Caswell, Kathryn L. Smith et al. · Toxicological Sciences · 0 citations