Open access
Aug 2026
Discovery of Selective Small-Molecule Ligands of SV2C by AI-Enhanced Virtual Screening and Experimental Validation
Synaptic vesicle glycoprotein 2C (SV2C) is a vesicular protein enriched in dopaminergic neurons of the basal ganglia that modulates dopamine storage and release, and its disruption is implicated in Parkinson’s disease (PD). Despite strong genetic and pathological links to PD, there are no selective small-molecule probe...
Alexander C. Brueckner, Matthew F. Martin, Sheenam Khuttan et al.
· bioRxiv · 0 citations