Jennifer E. Snyder-Cappione

Use of a 50-Marker Mass Cytometry Intracellular Cytokine Staining Panel Reveals Unforeseen Functional Diversity Within Cell Therapy Products 2258158

Despite significant investment, most cancer therapeutics, including CAR T cell therapies, fail in the clinic. Functional assessment of CAR T cells is typically limited to Th1 cytokines (for example, IFNγ), overlooking the known heterogeneity of the T cell subsets that make up the products, including populations w...