PepChem, a deep learning model utilizing novel, molecular-level peptide representations that enable predictions for sidechain modifications, bridges the critical gap in PTM-aware immune recognition prediction, with immediate applications in autoimmunity, cancer, and infectious disease.
A. Dumitrescu, Dani Korpela, Adrian M. Bebenek et al.· bioRxiv· 0 citations
TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.
N. Kehl, T. Wagner, Simon Steiger et al.· Cancer Cell· 1 citation
Tertiary lymphoid structures are reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immunotherapies, and are found to be reservoirs of tumour-specific T cells with stem-like progenitor features that could be leveraged by T cell immune pressure.
Alexander B. Afeyan, Adi Nagler, Chloe R. Tu et al.· Nature· 2 citations
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