Author

Jennifer W. Gin

3 papers indexed here

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Open access Oct 2026

Adaptive rewiring of NADPH electron flow reveals escape routes from redox-balance-based growth coupling in Escherichia coli.

Redox-balance-based growth coupling links oxidoreductase activity to cellular fitness and can enable high-throughput enzyme selection and strain evolution. However, because growth reflects the fitness of the whole cell, metabolic adaptation can circumvent the intended selective pressure. Here, we investigated the evolu...

Aidan E. Cowan, Mason Hillers, De-Tong Wu et al. · Metabolic Engineering · 0 citations

Open access Oct 2026

Replacing anaerobic fermentation with reverse β-oxidation enables growth-coupled evolution for enhanced fatty-alcohol production

Engineering robust fermentation hosts remains a barrier to scalable biomanufacturing. In this work we replace canonical mixed-acid fermentation in Escherichia coli with a redox‑balanced reverse β‑oxidation (rBOX) pathway that produces medium‑chain fatty alcohols and is bioenergetically equivalent to ethanol ferme...

Bridgie Cawthon, Aidan E. Cowan, Zen Yoshikawa et al. · Nature Communications · 0 citations

Open access Oct 2026

Orchestrating polyketide synthase-derived aldehyde metabolism for Streptomyces biomanufacturing.

Advances in metabolic engineering have enabled the integration of diverse non-native reactions into microbial hosts, providing sustainable alternatives to petrochemical manufacturing. We previously developed a modular polyketide synthase (PKS)-based platform in Streptomyces albus for producing 17 diols, amino alcohols,...

Q. Dan, Xi-Na Wang, Yan Chiu et al. · Metabolic Engineering · 0 citations