Author

Jenny Tang

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Open access Aug 2026

Covalent Stabilizers of the Interaction Between 14-3-3σ and Estrogen Receptor‑α.

Selective stabilization of complexes formed by the hub protein 14-3-3 represents an emerging mechanism for the modulation of therapeutically relevant targets. In this letter, we describe a hit-finding campaign designed to identify small molecule stabilizers of the interaction between 14-3-3σ and the estrogen receptor a...

R. Jain, Mark Knapp, S. Kochanek et al. · ACS Medicinal Chemistry Lett... · 1 citation

Open access Sep 2026

The Scope Concept: Defined Chemical Space for Identifying Ligand-Efficient, Tractable Hits Applied to Drug Discovery Targets Trypanosomal CLK1, 14–3–3/Estrogen Receptor-α, and SARS-CoV-2 Mpro

Scope is a hit-finding concept that explores a chemical space in between fragments and fully elaborated molecules from traditional low molecular weight (LMW) libraries. It emphasizes high medicinal chemistry tractability through a focus on compound quality, ligand efficiency, and selected physical-chemical property r...

J. Jansen, Wilian A. Cortopassi, Daniel Fuller et al. · Journal of Chemical Informat... · 1 citation