Open access
Aug 2026
Skeletal Muscle Stem Cell-Derived Myonuclei Adopt Divergent Terminal Transcriptional States in Adult and Aged Muscle In Response to a Hypertrophic Stimulus
By defining the age-associated fate of MuSC fusion to muscle fibers, it is provided potential targets for modulating muscle plasticity and predicts Runx1 may function as a master regulator of MuSC-Derived myonuclear specialization in response to MOV.
Nicholas T. Thomas, Jensen Goh, Kevin A. Murach et al.
· bioRxiv · 0 citations