Open access
Oct 2026
Sequence Scanning Improves Accuracy for Antibody-Antigen and Molecular Glue Ternary Complex Cofolding.
Accurately modeling biomolecular interactions is crucial for understanding biological function and can accelerate drug discovery efforts. Deep-learning-based cofolding methods such as AlphaFold3 and Boltz-2 can successfully predict many different biomolecular complexes. However, these models show lower success rates in...
Stephanie M. Linker, Tobias Ploetz, Andreas Evers et al.
· ChemMedChem · 0 citations