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Jesse C. Nussbaum

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Open access Oct 2026

An open-label, Phase 1 study to evaluate the drug-drug interaction between ulonivirine and the combined oral contraceptive levonorgestrel/ethinyl estradiol in female participants without HIV

ABSTRACT Ulonivirine is a non-nucleoside reverse transcriptase inhibitor in development as an oral, once-weekly treatment for HIV-1 in combination with investigational islatravir. The effect of ulonivirine on the pharmacokinetics of an oral contraceptive, levonorgestrel (LNG)/ethinyl estradiol (EE) was evaluated in fem...

Makeda L. Robinson, Gillian Gillespie, Bhargava Kandala et al. · 0 citations
Open access Oct 2026

Open-label Phase 1 study to evaluate drug-drug interactions between ulonivirine and islatravir in adults without HIV

No clinically meaningful DDIs were observed between ulonivirine 200 mg and islatravir 2 mg, supporting continued development of this combination for HIV-1 treatment, and safety parameters were comparable among all three periods.

Jesse C. Nussbaum, Michelle M. Pham, R. Vargo et al. · 0 citations

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