Author

Jessica C. McAfee

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Open access Oct 2026

Systematic Functional Interrogation of Neurodevelopmental Disorder Risk Variants

Neurodevelopmental disorders (NDDs) are highly polygenic, yet the functional consequences of most associated non-coding variants remain unclear. We used a massively parallel reporter assay (MPRA) to test 727 NDD-associated non-coding variants in human neural progenitors, identifying 38 expression-modulating variants (e...

Alejandro Gomez, Jessica C. McAfee, H. Min et al. · bioRxiv · 0 citations

Open access Sep 2026

Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants.

Genetic association studies have identified hundreds of largely noncoding loci associated with interindividual differences in the structure of the human cortex, although the specific functional variants contributing to these phenotypes are unknown. Here we implemented a massively parallel reporter assay to measure the...

Nana Matoba, Jessica C. McAfee, O. Krupa et al. · Nature Neuroscience · 0 citations