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Author

Jessica Mella

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2 papers indexed here

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Open access Sep 2026

Emerin loss of function inhibits MyoD-driven differentiation of human iPSCs into skeletal myotubes

Loss of function of the nuclear lamina-associated protein emerin causes Emery-Dreifuss muscular dystrophy (EDMD). Efforts to define emerin’s essential functions in skeletal muscle have been limited by poor concordance between mouse models and human disease phenotypes. Here, we adapt transgene-driven differentiation of...

Tracy A. Knight, Jessica Mella, Daniel Chen et al. · 0 citations
Open access Sep 2026

Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis

Hundreds of mutations to the broadly expressed LMNA gene cause disease primarily within cardiac, muscular, and adipose tissues1. Tissue-specific pathogenesis arises when mutant protein dysfunction collides with the unique demands of a specific cell type. Here, we decipher the cell-type-specific consequences of ∼15,000...

Jessica Mella, Abigail E. Hein, Navraj Lally et al. · 0 citations

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