Author

JH Kordower

2 papers indexed here

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Open access Jul 2026

Preformed Fibril Seeding Reshapes the Phosphorylated α-Synuclein Proximal Proteome in the Olfactory Bulb

Background Aggregated alpha-synuclein (αsyn) phosphorylated at serine 129 (PS129) accumulates in synucleinopathies, with the olfactory bulb (OB) being severely affected. Non-aggregated physiological PS129 is abundant in the mammalian OB, where it likely modulates αsyn-protein interactions. The impact of aggregation on...

Solji G. Choi, Atousa Bahrami, Jayda B. Duvernay et al. · bioRxiv · 0 citations

Editorial Open access Sep 2026

Co- and multipathologies need serious consideration for understanding Parkinson's disease pathogenesis and designing novel experimental therapeutic strategies

Parkinson ’ s disease (PD) is pathologically de ﬁ ned by the presence of aggregated α -synuclein in the form of Lewy bodies and Lewy neurites. 1 – 4 Considerable interest has focused on anti-α -synuclein immunotherapy as a potential disease-modifying strategy for PD, but initial phase 2a clinical trials examining this...

A. Boehringer, L. Kalia, B. Bloem et al. · Journal of Parkinson's Disea... · 0 citations