Review
Open access
Oct 2026
Pharmacological regulation of chondrocyte ferroptosis by plant-derived metabolites in osteoarthritis: from molecular mechanisms to targeted nanodelivery
Osteoarthritis (OA) lacks approved disease-modifying pharmacotherapy. Chondrocyte ferroptosis—iron-dependent phospholipid peroxidation caused by disrupted iron handling, lipid metabolism, and antioxidant defense—has been implicated in cartilage degeneration and is pharmacologically suppressible in experimental models....
Tian-Ci Guo, Qi Liu, Ji-Da Wang et al.
· Frontiers in Pharmacology · 0 citations