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Review Open access Oct 2026

SPP1+ macrophages in fibrosis.

ABSTRACT Fibrosis is a common end-stage pathological process in many chronic diseases and is characterized by excessive extracellular matrix (ECM) deposition and progressive tissue dysfunction. Effective antifibrotic therapies remain limited, and macrophages are increasingly recognized as key regulators of fibrogenesis...

Qing Bi, Ji-Chen Wang, Dong-Min Lai et al. · 0 citations
Open access Oct 2026

Sensory neuron-derived CGRP ameliorates kidney injury and fibrosis via monocytes and macrophages

Acute kidney injury (AKI) and its progression to chronic kidney disease (CKD) remain major unmet clinical challenges for which effective therapies are lacking. Although sensory neurons are recognized as key regulators of tissue injury and repair via neuroimmune crosstalk, their organization and function within the kidn...

Lei Wang, Huai-Kang Li, Ji Feng et al. · 0 citations

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