Author

Ji-Guang Yang

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Review Open access Sep 2026

Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases

The brain was long been regarded as an immune-privileged organ with a lack of lymphatic drainage, partly because of the absence of parenchymal lymphatic vessels. This long-held doctrine has been challenged by recent advancements in central lymphatic vascular biology. The central drainage network, which consists of the...

Shixin Ding, Ji-Guang Yang, Ze Wang et al. · Translational Neurodegenerat... · 0 citations

Open access Aug 2026

Integrated single-cell and bulk transcriptomic analysis identifies a novel senescent fibroblast subtype associated with poor prognosis in acral melanoma

Highlights • A high-resolution single-cell atlas of acral melanoma was constructed, revealing 10 major cell types and 16 melanoma subpopulations.• A novel senescent fibroblast subtype (sCAF_CDKN2A) was identified as a key driver of poor prognosis in acral melanoma.• SEMA6A, KIT, COL3A1, and VCAN were identified and val...

Ming Jing, Zhenyu Xu, Zhenqiang Ruan et al. · Translational Oncology · 0 citations