Author

Ji-Hong Zhang

2 papers indexed here

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Review Open access Sep 2026

Positive-Sense RNA Viruses Reprogramming Membrane Contact Sites to Remodel Organelles and Control Cell Fate

Eukaryotic cells rely on a highly coordinated organelle network to maintain metabolism, signaling, stress adaptation and cell survival. Membrane contact sites (MCSs) provide essential platforms for inter-organelle communication. As obligate intracellular parasites, less attention has been given to how viral perturbatio...

Duo Zhang, Liqingyang Wang, Xiao-Kui Zhang et al. · Viruses · 0 citations

Open access Jul 2026

Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.

This work unveils POLRMT as a metabolic gatekeeper that licenses CSC plasticity through KDM6B-α-KG/H3K27me3-mediated chromatin remodeling, proposing the mitochondrial transcription machinery as a therapeutic target for dismantling the CSC hierarchy in CRC.

Lei Tang, Siheng Nie, Jia-Long Qi et al. · Cell Death and Differentiati... · 0 citations