ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression.
BACKGROUND Tumor-associated macrophages (TAMs), as core components of the triple-negative breast cancer (TNBC) tumor microenvironment (TME), can promote tumor progression. Ferroptosis has been shown to be involved in TNBC progression, but its regulatory mechanisms in TNBC TAMs remain incompletely understood. METHODS...