Cognitive Flexibility and Cortical Transcriptomic Correlates of Individual Differences in Mice Following Prolonged Voluntary Ethanol Drinking.
Prolonged alcohol consumption is associated with cognitive dysfunction, but behavioral outcomes vary across individuals. We combined prolonged voluntary alcohol drinking, a cross-modal rule-switching task, and cortical RNA sequencing in male C57BL/6J mice to examine behavioral and molecular heterogeneity. Alcohol-drink...