Aug 2026
Decoding mechanoregulation in immunological synapses using biomimetic artificial cells
Xiaolei Yu, Vincent Mukwaya, Min-Xing Yue et al.
· Nature Methods · 0 citations
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Open access
Aug 2026
Rapid discovery of monoclonal antibodies via high-throughput single BCR affinity sequencing
Abstract To jointly capture antigen-binding affinity and paired heavy–light-chain sequences at scale has remained a bottleneck for monoclonal antibody discovery. Here, we present Antigen Affinity BCR-seq (AAB-seq), a high-throughput single-cell sequencing platform that can obtain the relative antibody–antigen affinity...
Mengzhu Hu, Qiuyu Lian, Xiaonan Cui et al.
· Nucleic Acids Research · 0 citations
Open access
Jul 2026
Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage
This work established miR‐197‐3p as a novel therapeutic regulator in OA and introduced a bioinstructive, injectable, and cell‐free strategy that integrates miRNA therapy and redox modulation for disease modification and cartilage regeneration.
Xuejie Cai, Zehui Lv, Chen Zhang et al.
· Advancement of science · 0 citations