Author

Jia-Chen Xu

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Sep 2026

Single-cell transcriptomics reveals a complex cell-cell communication network driven by myofibroblast-derived collagen in esophageal squamous cell carcinoma.

Fibroblasts are pivotal regulators of tumor development, progression, and therapeutic resistance in human malignancies. However, their functional diversity and cellular heterogeneity in esophageal squamous cell carcinoma (ESCC) remain largely elusive. In the present study, we constructed a high-resolution single-cell t...

Xiao-Wei Chen, Yuan-Yuan Lei, Da-Zhi Pang et al. · Cancer Letters · 0 citations

Open access Aug 2026

Genomic Profiling, Risk Stratification, and Post-Transformation Treatment Outcomes in Patients with Transformed Small-Cell Lung Cancer: A Multicenter Analysis.

BACKGROUND Transformed small-cell lung cancer (T-SCLC) is an increasingly recognized resistance mechanism in EGFR-mutant lung adenocarcinoma. This study aimed to identify early predictors of histologic transformation and evaluate post-transformation treatment outcomes. METHODS We retrospectively collected 163 T-SCLC...

Ruolin Gao, Zhenxiang Li, Jie-Ying Huang et al. · Lung Cancer · 0 citations