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Jia-Cheng Liu

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Oct 2026

Structure-guided identification and functional evaluation of small-molecule candidates predicted to target the LAG-3/MHC-II interface.

Small-molecule modulators may complement antibody therapy, offering potential advantages such as optimizable chemical structures, improved tumor accessibility, and better flexibility in pharmacokinetic control. Lymphocyte activation gene-3 (LAG-3) is an inhibitory immune checkpoint receptor that suppresses T-cell funct...

Ke-Jia Ren, Peng-Shan Li, Jia-Cheng Liu et al. · 0 citations

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