Jia-Cheng Sun

Targeting pro-senescent PTGS2+ macrophages alleviates chondrocyte senescence and osteoarthritis progression.

Macrophages contribute to osteoarthritis (OA) pathogenesis, but how specific macrophage states influence chondrocyte senescence remains unclear. Using single-cell RNA sequencing of naturally aged mouse joints, we identified a PTGS2-high macrophage subset associated with joint senescence. In a surgically induced OA mode...