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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jia-Hai Zhou

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Aug 2026

Metal Coordination Dynamics Governs Selective Halogenation in α-KG/Fe-Dependent Halogenase SyrB2.

α-Ketoglutarate (α-KG)-dependent nonheme iron enzymes catalyze a diverse array of oxidative transformations essential for natural product biosynthesis. However, the mechanism by which α-KG/Fe-dependent halogenases achieve selective halogenation while circumventing the thermodynamically favored hydroxylation pathway rem...

Wen-Li Yuan, Jia-Yong Huang, Jia Liu et al. · 0 citations
Aug 2026

A Cytochrome P450 Enzyme-Catalyzed Acetyl Migration in Cyanogramide Biosynthesis.

It is demonstrated that the cytochrome P450 monooxygenase CyaI catalyzes an oxidation reaction through a zwitterionic intermediate and facilitates a subsequent unusual C→N acetyl migration, which triggers a spontaneous intramolecular cyclization to forge the imidazolidin-4-one ring during 1 biosynthesis.

Yiguang Zhu, Yongchao Wang, Li-Ping Zhang et al. · 0 citations
Jul 2026

Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates.

A small-sample, accelerated evolution strategy that integrates focused rational iterative site-specific mutagenesis (FRISM) with the EVOLVEpro model is reported, providing a robust, "lightweight" machine learning framework for the rapid development of new-to-nature photoenzymatic transformations.

Hongkui Wang, Jiafan Xu, Jiahai Zhou et al. · 0 citations

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