Open access
Oct 2026
Deciphering Vascular Smooth Muscle Cell Phenotype Switching via Integrated Single-Cell Transcriptomics and Machine Learning: CX3CR1 and COL1A1 as Novel Diagnostic Biomarkers for Atherosclerosis
Background: Atherosclerosis is a chronic inflammatory disease of the arterial wall in which immune-cell accumulation and vascular stromal remodeling jointly shape plaque progression and stability. Because bulk-tissue transcriptomes combine signals from multiple cell types, the cellular origin of candidate expression ma...
Zhi-Qi Wang, Zhen-Yu Zhao, Zhi-Xi Hu et al.
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