Regulatory T cells in the bone marrow microenvironment: homeostatic crosstalk, disease remodeling, and therapeutic opportunities
Regulatory T cells (Tregs) help maintain immune balance in hematopoietic niches by interacting with the bone marrow microenvironment. Under normal conditions, surrounding cells send signals that affect Treg movement, their length of stay in the bone marrow, their number and activity. In turn, Tregs affect hematopoietic...