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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jia Huang

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2 papers indexed here

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Oct 2026

Structural Modifications Redirect Phenylpyrazole Ectoparasiticides from the Ion Channel Pore to an Allosteric Site on GABA Receptors

Phenylpyrazole ectoparasiticides, exemplified by fipronil, act as noncompetitive antagonists of arthropod GABA receptors by blocking the ion channel pore. Here, we investigated the molecular mechanism of the newer phenylpyrazole nicofluprole using Drosophila melanogaster. CRISPR/Cas9-mediated mutagenesis and pharmaco...

Tian-Hao Zhou, Zi-Han Cheng, Hong-Lei Xie et al. · 0 citations
Open access Sep 2026

Host-mediated insecticide sequestration in target-site-resistant pests impacts parasitoid fitness and evolution.

Insecticide resistance poses a major challenge to global pest management, yet its cascading effects on ecological networks remain poorly understood. Here, we show that target-site-resistant herbivorous insects can accumulate unmetabolized insecticides and inadvertently function as "toxic prey," impairing the fitness of...

Zhi-Han Liu, Ting Feng, Lei Guo et al. · 0 citations

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