Author

Jia-Hui Guan

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Sep 2026

SwinTransRNA: A Swin Transformer-Based Framework for Accurate Prediction of RNA Subcellular Localization

RNA subcellular localization determines the regulatory context in which microRNAs (miRNAs), circular RNAs (circRNAs), and long noncoding RNAs (lncRNAs) exert their functions, yet these RNA classes differ greatly in sequence length and circularity, making fixed-length raw-sequence representations inconvenient for cros...

Bo-Wen Shi, Xu-Xin He, Yen-Peng Chiu et al. · Journal of Chemical Informat... · 0 citations

Preprint Aug 2026

PertMind: Eliciting Emergent Biological Reasoning in LLM via Reinforcement Learning on Cellular Perturbation Data

Large language models can describe mechanisms, yet scalable post-training still depends on costly, manually curated biological reasoning traces. Here we show that cellular perturbation atlases can instead become reinforcement-learning environments, where measured gene responses provide computable rewards for biological...

Zhen-Chao Tang, Xiaogang Xu, Tian-Xu Lv et al. · 0 citations

Jul 2026

DDI-MMAF: Multi-modal affine fusion of visual and semantic representations for anticancer drug synergy prediction.

DDI-MMAF is proposed, a lightweight cross-modal framework that avoids using explicit high-dimensional omics profiles as direct model inputs and enables accurate synergy prediction from raw minimalist inputs, offering a practical and efficient computational solution for cost-effective drug combination discovery.

Hao Li, Qianhui Jiang, Jiahui Guan et al. · European journal of medicina... · 0 citations