Open access
Aug 2026
Gram-scale microbial synthesis of hypericin, a low-abundance complex phytochemical drug candidate
This work re-engineer the polyketide biosynthetic pathways in Cladosporium fulvum and overcome substrate inhibition and metabolic inefficiency, achieving scalable and plant-pathway-independent biomanufacturing of hypericin.
Qing-Juan Cui, Xin Shi, Jia-Hui Li et al.
· National Science Review · 0 citations