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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Jiahui Zhang

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2 papers indexed here

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Open access Oct 2026

TCASIA: an integrative atlas linking alternative splicing landscapes for cancer immunotherapy

Abstract Background Identifying robust predictive biomarkers for immune checkpoint blockade (ICB) remains a challenge. While alternative splicing (AS) shapes tumor immunity, the lack of large-scale, consensus-based datasets constrains the characterization of ICB-specific splicing landscapes. Methods We developed TCASIA...

Yi-Hao Zhang, Yun-Zhi Guo, Hai-Tao Wang et al. · 0 citations
Jul 2026

Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization.

Mechanistic insights are provided into how POU4F1, a BLBC-specific transcription factor, orchestrates intercellular crosstalk to establish an immunosuppressive, tumor-supportive microenvironment, and indicate that targeting POU4F1 may represent a promising therapeutic strategy for BLBCs.

Jia-Hui Zhang, Nan-Yan Miao, Yun-Zhi Guo et al. · 0 citations

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