Machine Learning-Guided Cofactor Engineering for Tunable Azaphilone Component Ratios in Monascus spp.
Monascus azaphilones (MAs) are bioactive compounds that have been utilized in food for over a millennium. These molecules are classified into orange (OMAs), yellow (YMAs), and red MAs (RMAs), with compositional ratios determining the product quality. Cofactors critically influence component ratios, but their individu...