Author

Jia-Jun Ding

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Open access Aug 2026

Design, synthesis and antiproliferative activity of pyridone derivatives as potent enhancer of zeste homologue 2/histone deacetylase dual inhibitors

Compound 15c warrants further investigation as a novel dual HDAC/EZH2 agent after molecular simulations revealed key interactions between 15c and both targets.

Zhaobang Tan, Jia-Jun Ding, Xin Chen et al. · RSC Advances · 0 citations