Open access
Sep 2026
RAMP3 is associated with macrophage-driven immune exclusion and promotes resistance to PD-1 blockade in breast cancer: integrated in vivo and single-cell transcriptomic analyses
The results suggest that RAMP3 contributed to the establishment of an immunosuppressive TME and integration with human clinical datasets supports further investigation of RAMP3 as a potential therapeutic target for overcoming resistance to immune checkpoint therapy in breast cancer.
Yan Zhang, Megumu Tanaka, T. Sakurai et al.
· Journal of Translational Med... · 0 citations