Open access
Jul 2026
Human single-cell atlas of proliferative diabetic retinopathy reveals a SOX15-overexpressing stromal population driving retinal fibrosis through the endothelin-1 -EDNRB axis
Key pathological features of the human PDR retina are identified, including pervasive neuroinflammation and selective loss of photoreceptor subpopulations, and the SOX15–EDN1-EDNRB axis is delineated as a novel mechanism driving retinal fibrosis.
Fen Tang, Wenjing He, Zhi-Jie Niu et al.
· Journal of Translational Med... · 0 citations