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An RBP-J–Hs2st1–2-O-sulfated heparan sulfate (HS)–IFNβ dependent molecular network that acts as a gatekeeper balancing macrophage fate inclinations in response to TNF is identified.
The tumor immune microenvironment plays a decisive role in tumor initiation, progression and therapeutic response. Spatial transcriptomics (ST) enables comprehensive analysis of the whole transcriptome or specific gene sets while preserving the original spatial location information within tissues, offering a revolution...
FPR1 and S100A9 are promising common biomarkers for AP and MAFLD, and may provide important insights into common mechanisms and therapeutic opportunities.
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