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Author

Jia-Lin Liu

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Sep 2026

Targeted O-GlcNAcylation enables functional rewiring of c-Myc.

Chemically induced proximity has transformed targeted protein degradation but has been applied far less extensively to directly reprogram protein function through post-translational modification (PTM). Here, we develop an O-GlcNAcylation-targeting Chimera (OGTAC) that recruits O-GlcNAc transferase (OGT) to the oncogeni...

Tong-Yang Xu, Zhi-Hao Guo, K. S. Khan et al. · 0 citations
Open access Jul 2026

A dual-receptor checkpoint primes enterovirus D68 for respiratory cell entry

Cryo-EM structures of historical and contemporary AFM-associated EV-D68 strains, together with their complexes bound to the third extracellular loop of MFSD6, reveal a glycan-mediated dual-lock mechanism that may enhance receptor specificity, prevent premature uncoating, and ensure productive infection only upon engage...

Shengjian Liang, Hao-Ran Guo, Zhili Xu et al. · 0 citations

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