Jia-Lu Wang

Engineered IFN-γ-Expressing Platelet-Like Microparticles Trigger Macrophage-Targeted Immunity to Eradicate Liver Metastases.

Immunotherapy for colorectal cancer liver metastasis is often compromised by a highly immunosuppressive hepatic microenvironment characterized by tolerogenic macrophages that act as a systemic immune sink. Here, given the potent but systemically toxic antitumor profile of interferon-γ (IFN-γ), we engineered hepatic mac...