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Review Sep 2026

Targeting KRAS-Mutant Lung Cancers.

KRAS mutations are the most common oncogenic driver alterations in non-small cell lung cancer (NSCLC) and define biologically heterogeneous diseases shaped by mutation subtype, co-mutation patterns, and immune contexture. Recent advances in structural and chemical biology have transformed KRAS from an undruggable targe...

E. Garbo, P. Scaparone, Hui Jing Hoe et al. · 0 citations
Sep 2026

Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection.

TP53 mutations occur early in malignant transformation as truncal events in tumor evolution and are therefore generally present in all descendant tumor cells, creating an immunological vulnerability. Here, we examined the immunogenicity and antigenicity of p53 neoantigens emerging from these truncal mutations. Comprehe...

Koji Haratani, Bruce R. Reinhold, J. Duke-Cohan et al. · 0 citations

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