Jia-Peng Bao

2'-O-Galloylhyperin attenuates osteoclastogenesis and estrogen-deficiency osteoporosis by targeting MLK3-mediated NF-κB signaling.

Estrogen deficiency-induced osteoporosis is largely driven by excessive osteoclast formation and bone resorption, but the direct pharmacological targets of flavonoid derivatives in osteoclast differentiation remain unclear. Here, we investigated the anti-osteoclastogenic activity and molecular mechanism of 2'-O-Galloyl...